Preferred Label : Human Monoclonal Antibody 216;
NCIt synonyms : MoAb 216;
NCIt definition : A naturally-occurring human IgM monoclonal antibody with potential antineoplastic
activity. Human monoclonal antibody 216, derived from the gene VH4-34, binds to the
glycosylated epitope CDIM on the surface of both malignant and normal B cells. Upon
binding to B cells, this antibody may crosslink two or more CDIM molecules, resulting
in the formation of cell membrane pores, the disruption of cell membrane integrity,
and B cell lysis; this mechanism of antibody-mediated cell death is direct and does
not involve mechanisms of complement-mediated cytotoxicity or antibody-dependent cell-mediated
cytotoxicity (ADCC). CDIM is the glyco-moiety of a 75kD B-cell cell surface glycoprotein.;
Origin ID : C62532;
UMLS CUI : C1831869;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
