Preferred Label : Seneca Valley Virus-001;
NCIt synonyms : Seneca Valley Virus;
NCIt related terms : SVV-001; NTX-010;
NCIt definition : A replication-competent oncolytic picornavirus with potential antineoplastic activity.
Administered systemically, Seneca Valley virus-001 specifically targets and infects
tumor cells with neuroendocrine characteristics. Upon infection, this agent replicates
intracellularly, resulting in tumor cell lysis and reduced tumor cell proliferation.
The selective tropism of virus replication may involve receptor-mediated internalization.;
Alternative definition : NCI-GLOSS: A virus being studied in the treatment of neuroendocrine tumors and other
types of cancer. Neuroendocrine tumors form from cells that release hormones in response
to a signal from the nervous system. The virus infects and breaks down these tumor
cells but not normal cells. It is a type of oncolytic virus.;
Molecule name : NTX-010;
NCI Metathesaurus CUI : CL365090;
Codes from synonyms : CDR0000665421; CDR0000665428; CDR0000665427;
Origin ID : C62524;
UMLS CUI : C2348179;
Semantic type(s)
- Virus [UMLS semantic type]
- Validated automatic mappings to NTBT
- concept_is_in_subset
