Fluorine F 18-fluoroazomycin Arabinoside

Preferred Label : Fluorine F 18-fluoroazomycin Arabinoside;

NCIt synonyms : 18F-FAZA; Fluoroazomycin Arabinoside F-18; 1H-Imidazole, 1-(5-Deoxy-5-(fluoro-18F)-alpha-D-; FAZA F-18; 18F-Fluoroazomycin Arabinoside;

NCIt definition : A radiofluorinated 2-nitroimidazole derivative with positron-emitting radioisotope activity. Upon administration, fluorine F 18-fluoroazomycin arabinoside is reduced under hypoxic conditions in the tumor microenvironment to a reactive species that covalently binds to intracellular macromolecules, providing a quantitative measure of viable hypoxic tissue when imaged with positron emission tomography. Compared to 18F-misonidazole, fluorine F 18-fluoroazomycin arabinoside has a lower octanol:water partition coefficient; it therefore has less tendency to accumulate in lipophilic tissues and exhibits a faster renal clearance, which may result in improved imaging of hypoxic tissue.;

UNII : UG7I3Y42PV;

InChIKey : LPZSRGRDVVGMMX-FJBGPTLJSA-N;

CAS number : 864084-85-5;

Details

Origin ID

C62520;

UMLS CUI

C1566975;

Automatic exact mappings (from CISMeF team)
- fluoroazomycin arabinoside [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- 18F-FAZA [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
UMLS correspondences (same concept)
- 18F-FAZA [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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