Phosphorodiamidate Morpholino Oligomer AVI-4126

Preferred Label : Phosphorodiamidate Morpholino Oligomer AVI-4126;

NCIt synonyms : AVI-4126; PMO AVI-4126; Oncomyc-NG;

NCIt definition : A c-Myc antisense phosphorodiamidate morpholino oligomer (PMO) with potential antineoplastic activity. Phosphorodiamidate morpholino oligomer AVI-4126 binds to c-Myc mRNA and blocks its translation, which may result in the death of tumor cells overexpressing c-Myc. Differing from traditional antisense oligodeoxynucleotides (ODNs), neutrally charged PMOs are composed of subunits of nucleic acid bases linked to a synthetic backbone and, so, are less prone to enzymatic degradation. c-Myc, a proto-oncogene overexpressed in a variety of cancers, is involved in cellular proliferation, differentiation, and apoptosis.;

Details

Origin ID

C62518;

UMLS CUI

C1450425;

Currated CISMeF NLP mapping
- AVI-4126 [MeSH concept]
- AVI-4126 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AVI-4126 [MeSH Supplementary Concept]
- AVI-4126 [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- RNA Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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