NCIt definition : An orally active second generation tetrathiomolybdate analog with anti-angiogenic
and antineoplastic activities. Tiomolibdate choline selectively chelates the copper
ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1
of copper and inhibiting its activity. Inhibition of SOD1 interferes with the activation
of several signal transduction pathways required for cellular proliferation and angiogenesis,
including those mediated by ERK1/2 and FAK and Src kinases. This results in an inhibition
of cell proliferation and angiogenesis as well as induction of apoptosis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It may prevent the
growth of new blood vessels that tumors need to grow. ATN-224 also blocks enzymes
that cells need to divide and grow, and it may kill cancer cells. It is a type of
antiangiogenesis agent and a type of superoxide dismutase inhibitor.;
UNII : FD57A79R4P;
InChIKey : NEYVHGQOGHJAAD-UHFFFAOYSA-N;
CAS number : 649749-10-0;
Molecule name : ATN-224; ATN 224; WTX-101; ALXN-1840;
Chemical formula : 2C5H14NO.MoS4;
Codes from synonyms : CDR0000633062; CDR0000633063;
Semantic type(s)