Preferred Label : Barasertib;
NCIt synonyms : Aurora Kinase Inhibitor AZD1152; 1h-pyrazole-3-acetamide, 5-((7-(3-(ethyl(2-(phosphonooxy)ethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)-;
NCIt definition : An orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline
Aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA)
with potential antineoplastic activity. Upon administration and rapid conversion from
the prodrug form in plasma, AZD1152-HQPA specifically binds to and inhibits Aurora
kinase B, which results in the disruption of spindle checkpoint functions and chromosome
alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently,
cell division and cell proliferation are inhibited and apoptosis is induced in Aurora
kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase
that functions in the attachment of the mitotic spindle to the centromere, is overexpressed
in a wide variety of cancer cell types.;
UNII : 16XC2U7W8N;
InChIKey : GBJVVSCPOBPEIT-UHFFFAOYSA-N;
CAS number : 722543-31-9;
Molecule name : AZD-1152; AZD 1152;
Chemical formula : C26H31FN7O6P;
Codes from synonyms : 60;
Origin ID : C62502;
UMLS CUI : C3253842;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- concept_is_in_subset
- has_target
