NCIt definition : A naturally occurring alcohol found in fruits and vegetables and used as an osmotic
diuretic. Mannitol is freely filtered by the glomerulus and poorly reabsorbed from
the renal tubule, thereby causing an increase in osmolarity of the glomerular filtrate.
An increase in osmolarity limits tubular reabsorption of water and inhibits the renal
tubular reabsorption of sodium, chloride, and other solutes, thereby promoting diuresis.
In addition, mannitol elevates blood plasma osmolarity, resulting in enhanced flow
of water from tissues into interstitial fluid and plasma.;
Alternative definition : NCI-GLOSS: A drug used to decrease swelling of the brain and to treat kidney failure.
Mannitol can also be used to open the blood-brain barrier, which allows anticancer
medicines to enter the brain and treat brain tumors.;
UNII : 3OWL53L36A;
InChIKey : FBPFZTCFMRRESA-KVTDHHQDSA-N;
CAS number : 69-65-8;
Drug name : Resectisol; Osmitrol;
Chemical formula : C6H14O6;
NCI Metathesaurus CUI : CL1659099;
NSC code : 407017;
ChEBI ID : CHEBI:16899;
Codes from synonyms : 03076; NSC0407017; CDR0000468771; 319;
Semantic type(s)