Denenicokin - CISMeF

Preferred Label : Denenicokin;

NCIt synonyms : L-methionyl(Human Interleukin-21); Recombinant Human Interleukin-21; rIL-21; IL-21; rhIL-21;

NCIt definition : A recombinant peptide similar to or identical to endogenous human cytokine interleukin-21 (IL-21) with potential antineoplastic activity. Denenicokin binds to and activates IL-21 receptors, expressed on T-cells, B-cells, dendritic cells (DC), and natural killer (NK) cells, modulating the proliferation and/or differentiation of T and B cells, promoting T cell survival, and increasing the cytolytic activity of cytotoxic T lymphocytes (CTLs) and NK cells.;

UNII : A4LY1V9F0H;

CAS number : 716840-32-3;

Details

Origin ID

C62492;

UMLS CUI

C1831593;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- B-Lymphocyte [NCIt concept]
- Dendritic Cell [NCIt concept]
- Natural Killer Cell [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Interleukin-21 Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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