Preferred Label : Immunotoxin CMD-193;
NCIt definition : A humanized immunotoxin directed against the Lewis Y antigen conjugated with calicheamicin,
a hydrophobic enediyne antibiotic, with potential antineoplastic activity. CMD193
binds to the Lewis Y antigen, a tetrasaccharide expressed on the cell surfaces of
many tumor cell types. Upon binding, CMD-193 is internalized, thereby delivering the
attached calicheamicin to Lewis Y antigen-expressing tumor cells. Calicheamicin binds
non-covalently to the minor groove of DNA and prompts conformational changes and DNA
oxidation, thereby inhibiting DNA synthesis and inducing apoptosis.;
CAS number : 1080645-97-1;
Molecule name : CMD-193; CMD 193;
Origin ID : C62480;
UMLS CUI : C1879965;
Semantic type(s)
- concept_is_in_subset
