NCIt definition : A 4-point scale for renal cell carcinoma that indicates the level of protein synthesis
activity in malignant cells based on the appearance of the nuclei. The grading ranges
from I (best prognosis) to IV (worst prognosis).;
Alternative definition : CDISC: A tumor grading system developed by Fuhrman et al (1982) that evaluates nuclear
grade, based on nuclear size, irregularity and nucleolar prominence, in renal cell
carcinomas. (Fuhrman SA, Lasky SA, Limas C. Prognostic significance of morphologic
parameters in renal cell carcinoma. Am J Surg Pathol. 1982 Oct;6(7):655-63.);