CpG-28 Oligodeoxynucleotide

Preferred Label : CpG-28 Oligodeoxynucleotide;

NCIt synonyms : CpG Oligodeoxynucleotide; CpG ODN;

NCIt definition : A synthetic oligodeoxynucleotide, containing unmethylated CpG motifs derived from bacterial DNA, with immunostimulatory activities. A CpG oligodeoxynucleotide (CpG ODN) binds to and activates a Toll-like receptor 9 (TLR9) and is taken up into cells by endocytosis; once internalized, it may activate numerous signaling transduction pathways resulting in the release of multiple cytokines. Through activation of TLR9, a CpG ODN can directly stimulate B-lymphocytes, dendritic and NK cells, resulting in an increase in innate immunity and antibody-dependant cell cytotoxicity (ADCC). Additionally, a CpG ODN can indirectly modulate T-cell responses, through the release of cytokines (IL-12 and IFN gamma), to induce a preferential shift to the Th1 (helper) phenotype resulting in enhanced CD8 cellular cytotoxicity.;

Molecule name : CpG-28;

PubMed : 16443949;

Details

Origin ID

C62280;

UMLS CUI

C0914671;

Currated CISMeF NLP mapping
- CPG-ODN [MeSH concept]
False automatic mappings
- Insert - dosing instruction imperative (qualifier value) [SNOMED CT concept]
- Inserting [ICNP action]
See also inter- (CISMeF)
- CPG-oligonucleotide [MeSH Supplementary Concept]
- CpG ODN 2216 [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CPG-ODN [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Toll-Like Receptor 9 [NCIt concept]

Keyword's position in hierarchy(ies) :

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