NCIt definition : An autoantibody against a red blood cell surface antigen that causes the cells to
clump when the blood is cooled below the normal body temperature (the clumping is
most pronounced at temperatures below 78 degrees). Presence of cold agglutinins may
be indicative of mycoplasmal pneumonia, mononucleosis, mumps, measles, scarlet fever,
some parasitic infections, cirrhosis of the liver, and some types of hemolytic anemia.;