L-Gossypol - CISMeF

Preferred Label : L-Gossypol;

NCIt definition : The levo-enantiomer of an orally bioavailable polyphenolic aldehyde, derived primarily from unrefined cottonseed oil, with potential antineoplastic activity. Mimicking the inhibitory BH3 (Bcl-2 homology 3) domain of endogenous antagonists of Bcl-2, L-gossypol binds to and inhibits various anti-apoptotic Bcl-2 proteins, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. This agent has greater affinity for Bcl-2 proteins than racemic gossypol.;

CAS number : 90141-22-3;

Details

Origin ID

C62178;

UMLS CUI

C1831823;

Currated CISMeF NLP mapping
- gossypol, (-)-Isomer [MeSH concept]
See also inter- (CISMeF)
- Gossypol [LOINC component]
- Gossypol (substance) [SNOMED CT concept]
- gossypol [MeSH concept]
- gossypol [SNOMED Notion]
- gossypol [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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