Quinapril - CISMeF

Preferred Label : Quinapril;

NCIt synonyms : Quinapril Base;

NCIt definition : A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels.;

UNII : RJ84Y44811;

InChIKey : JSDRRTOADPPCHY-HSQYWUDLSA-N;

CAS number : 85441-61-8;

Chemical formula : C25H30N2O5;

ChEBI ID : CHEBI:8713;

Details

Origin ID

C62074;

UMLS CUI

C0072857;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing quinapril (medicinal product) [SNOMED CT concept]
- Quinapril [MeSH Descriptor]
- Quinapril [ICD-11 Extension code]
- Quinapril [LOINC component]
- Quinapril (substance) [SNOMED CT concept]
- quinapril [ATC Code]
- quinapril [MeSH concept]
Validated automatic mappings to BTNT
- quinapril [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Quinapril Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Quinapril Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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