NCIt definition : An indazole derivative with antiemetic properties. As a selective serotonin receptor
antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3
(5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced
nausea and vomiting.;
Alternative definition : NCI-GLOSS: The active ingredient in a drug used to treat nausea and vomiting caused
by cancer treatment. Granisetron is a type of serotonin receptor antagonist and a
type of antiemetic.;