Cephalothin - CISMeF

Preferred Label : Cephalothin;

NCIt synonyms : Cephalothin Base;

NCIt definition : A semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.;

UNII : R72LW146E6;

InChIKey : XIURVHNZVLADCM-IUODEOHRSA-N;

CAS number : 153-61-7;

Chemical formula : C16H16N2O6S2;

ChEBI ID : CHEBI:124991;

Details

Origin ID

C62021;

UMLS CUI

C0007735;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Cefalotin [ICD-11 Extension code]
- Cefalotin (substance) [SNOMED CT concept]
- Cephalothin [ICD-11 Extension code]
- Cephalothin [LOINC component]
- Product containing cefalotin (medicinal product) [SNOMED CT concept]
- cefalotin [ATC Code]
- cephalothin [Substance BNPC]
- cephalothin [SNOMED Notion]
- cephalothin [MeSH Descriptor]
- cephalothin [MeSH concept]
Validated automatic mappings to BTNT
- cefalotin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Cephalothin Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Cephalothin Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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