Trientine Hydrochloride

Preferred Label : Trientine Hydrochloride;

NCIt synonyms : N,N-bis (2-aminoethyl)-1,2-ethanediamine Dihydrochloride;

NCIt definition : The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).;

UNII : HC3NX54582;

InChIKey : WYHIICXRPHEJKI-UHFFFAOYSA-N;

CAS number : 38260-01-4;

Drug name : Syprine;

Chemical formula : C6H18N4.2HCl;

Codes from synonyms : 50560;

Details

Origin ID

C61987;

UMLS CUI

C0770325;

Automatic exact mappings (from CISMeF team)
- trientine [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Trientine hydrochloride (substance) [SNOMED CT concept]
- trientine hydrochloride [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Trientine [NCIt concept]
is_salt_form_of
- Trientine [NCIt concept]

Keyword's position in hierarchy(ies) :

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