Trandolapril - CISMeF

Preferred Label : Trandolapril;

NCIt definition : A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : 1T0N3G9CRC;

InChIKey : VXFJYXUZANRPDJ-WTNASJBWSA-N;

CAS number : 87679-37-6;

Drug name : Mavik;

Chemical formula : C24H34N2O5;

Codes from synonyms : 32056;

Details

Origin ID

C61978;

UMLS CUI

C0076891;

Automatic exact mappings (from CISMeF team)
- trandolaprilat [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing trandolapril (medicinal product) [SNOMED CT concept]
- Trandolapril (substance) [SNOMED CT concept]
- trandolapril [ATC Code]
- trandolapril [Substance BNPC]
- trandolapril [MeSH Supplementary Concept]
- trandolapril [MeSH concept]
Validated automatic mappings to BTNT
- trandolapril [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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