" /> Thioguanine Anhydrous - CISMeF





Preferred Label : Thioguanine Anhydrous;

NCIt definition : The anhydrous salt form of thioguanine, a synthetic guanosine analogue antimetabolite, with antineoplastic activity. Thioguanine is phosphorylated by hypoxanthine-guanine phosphoribosyltransferase to 6-thioguanylic acid (TGMP) and upon conversion to thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP), this agent is incorporated into DNA and RNA, resulting in inhibition of DNA and RNA synthesis and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine ribonulceotide synthesis.;

UNII : WIX31ZPX66;

InChIKey : WYWHKKSPHMUBEB-UHFFFAOYSA-N;

CAS number : 154-42-7;

Chemical formula : C5H5N5S;

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10/07/2025


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