Streptomycin - CISMeF

Preferred Label : Streptomycin;

NCIt definition : An aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial activity. Streptomycin irreversibly binds to the 16S rRNA and S12 protein within the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, streptomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.;

UNII : Y45QSO73OB;

InChIKey : UCSJYZPVAKXKNQ-HZYVHMACSA-N;

CAS number : 57-92-1;

Chemical formula : C21H39N7O12;

ChEBI ID : CHEBI:17076;

Details

Origin ID

C61952;

UMLS CUI

C0038425;

False automatic mappings
- Aminoglycosides [ICD-10 Sub-category (who)]
- Poisoning by, adverse effect of and underdosing of aminoglycosides [ICD-10 Sub-category]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing streptomycin (medicinal product) [SNOMED CT concept]
- Streptomycin [LOINC component]
- Streptomycin (substance) [SNOMED CT concept]
- streptomycin [ATC Code]
- streptomycin [ATC Code]
- streptomycin [MeSH concept]
- streptomycin [SNOMED Notion]
- streptomycin [MeSH Descriptor]
Validated automatic mappings to BTNT
- streptomycin [ATC Code]
- streptomycin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Streptomycin Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Streptomycin Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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