Preferred Label : Lorazepam;
NCIt synonyms : 7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one;
NCIt related terms : Ativan;
NCIt definition : A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative
properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric
acid on the GABA receptors by binding to a site that is distinct from the GABA binding
site in the central nervous system. This leads to an increase in chloride channel
opening events, a facilitation of chloride ion conductance, membrane hyperpolarization,
and eventually inhibition of the transmission of nerve signals, thereby decreasing
nervous excitation.;
Alternative definition : NCI-GLOSS: A drug that is used to treat anxiety and certain seizure disorders (such
as epilepsy), and to prevent nausea and vomiting caused by chemotherapy. It belongs
to the families of drugs called antiemetics and benzodiazepines.;
UNII : O26FZP769L;
InChIKey : DIWRORZWFLOCLC-UHFFFAOYSA-N;
CAS number : 846-49-1;
Drug name : Ativan;
Chemical formula : C15H10Cl2N2O2;
NSC code : 289758;
Codes from synonyms : NSC0289758; CDR0000467846; 313;
Origin ID : C619;
UMLS CUI : C0024002;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
