Polymyxin B - CISMeF

Preferred Label : Polymyxin B;

NCIt definition : A mixture of the polypeptides polymyxins B1 and B2, both obtained from Bacillus polymyxa strains, with antimicrobial activity. Polymyxin B exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.;

UNII : J2VZ07J96K;

CAS number : 1404-26-8;

Details

Origin ID

C61894;

UMLS CUI

C0032535;

False automatic mappings
- polymyxin B(1) [MeSH concept]
- polymyxin B(1) [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Antibiotic [UMLS semantic type]
UMLS correspondences (same concept)
- Polymyxin B [ICD-11 Extension code]
- Polymyxin B [LOINC component]
- Polymyxin B (substance) [SNOMED CT concept]
- Product containing polymyxin B (medicinal product) [SNOMED CT concept]
- polymyxin B [MeSH Descriptor]
- polymyxin B [MeSH concept]
- polymyxin b [ATC Code]
- polymyxin b [ATC Code]
- polymyxin b [ATC Code]
- polymyxin b [ATC Code]
- polymyxin b [ATC Code]
- polymyxin b [SNOMED Notion]
Validated automatic mappings to BTNT
- polymyxin b [ATC Code]
- polymyxin b [ATC Code]
- polymyxin b [ATC Code]
- polymyxin b [ATC Code]
- polymyxin b [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Polymyxin B Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Polymyxin B Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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