" /> Pamidronic Acid - CISMeF





Preferred Label : Pamidronic Acid;

NCIt related terms : Pamidronate;

NCIt definition : An amino- bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Pamidronic acid binds to and adsorbs onto hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated bone resorption, pamidronic acid decreases bone turnover rate, stabilizes the bone matrix and reduces hypercalcemia.;

Alternative definition : NCI-GLOSS: A drug that is used to treat hypercalcemia (too much calcium in the blood) and cancer that has spread to the bones. It belongs to the family of drugs called bisphosphonates.;

UNII : OYY3447OMC;

InChIKey : WRUUGTRCQOWXEG-UHFFFAOYSA-N;

CAS number : 40391-99-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 40391-99-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C3H11NO7P2;

Codes from synonyms : CDR0000045175; 50681; 383;

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09/05/2024


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