" /> Milrinone - CISMeF





Preferred Label : Milrinone;

NCIt definition : A cardiovascular bipyridine agent and phosphodiesterase (PDE) III inhibitor, with positive inotropic and vasodilator activities. Upon administration, milrinone selectively inhibits PDE-mediated degradation of cyclic adenosine monophosphate (cAMP) in the heart and vascular muscles, thereby increasing cAMP and activates protein kinase A (PKA). This leads to phosphorylation of calcium ion channels and improve myocardium contractile force. Milrinone also causes vasodilation in arteriolar and venous vascular smooth muscle.;

Alternative definition : ACC/AHA: Milrinone is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility, decrease pulmonary vascular resistance, and as a systemic vasodilator.;

UNII : JU9YAX04C7;

InChIKey : PZRHRDRVRGEVNW-UHFFFAOYSA-N;

CAS number : 78415-72-2;

Chemical formula : C12H9N3O;

ChEBI ID : CHEBI:50693;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
30/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.