Preferred Label : Mercaptopurine Anhydrous;
NCIt definition : The anhydrous form of mercaptopurine, a thiopurine-derivative antimetabolite with
antineoplastic and immunosuppressive activities. Produced through the metabolism of
mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine
metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate
(T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby
blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent
is also incorporated into DNA in the form of deoxythioguanosine, which results in
the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine
ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors
of de novo purine synthesis.;
UNII : PKK6MUZ20G;
InChIKey : GLVAUDGFNGKCSF-UHFFFAOYSA-N;
CAS number : 50-44-2;
Chemical formula : C5H4N4S;
ChEBI ID : CHEBI:2208; CHEBI:50667;
Origin ID : C61832;
UMLS CUI : C1881785;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
