NCIt definition : A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential
chemosensitization and radiosensitization activities. Although the exact mechanism
remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes
and disrupts lysosomal function and integrity, thereby leading to host cell death.
Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this
agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving
lysosomal degradation that minimizes the production of reactive oxygen species (ROS)
related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.
Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration.;