NCIt definition : A synthetic agent chemically related to the opiates with anti-diarrheal properties.
Loperamide decreases gastro-intestinal motility by effects on the circular and longitudinal
muscles of the intestine. Part of its anti-diarrheal effect may be due to a reduction
of gastro-intestinal secretion produced by opioid receptor binding in the intestinal
mucosa. (NCI04);