NCIt definition : A blue, aniline-derived dye with antifungal and antimitotic properties. Gentian violet
(GV) dissociates into positive (GV ) and negative ions (Cl-) that penetrate both gram-positive
and gram-negative bacterial cells. The GV ions interact with negatively charged components
of the bacterial cell wall including lipopolysaccharide, peptidoglycan and DNA. This
agent is also a mutagen and mitotic poison. GV elicits a photodynamic action mediated
by a free-radical mechanism. Furthermore, this agent dissipates the action potential
on prokaryotic or eukaryotic membranes by inducing permeability, thereby leading to
respiratory inhibition and subsequent cell death.;