Preferred Label : Fenoldopam;
NCIt definition : A benzazepine derivative with vasodilatory and antihypertensive properties. Fenoldopam,
a dopamine (DA) receptor agonist, binds specifically to peripheral DA1 receptors and
to alpha-2 adrenoceptors with moderate affinity. However, this agent exhibits no significant
affinity to DA2, other alpha adrenergic, beta adrenergic, muscarinic, or serotonergic
receptors. Receptor binding modulates the transmembrane flux of ions, thereby stimulating
adenylate cyclase activity, as well as the release of prolactin. This results in vasodilatation,
increased renal blood flow thereby enhancing natriuresis and diuresis leading to a
lowering in diastolic blood pressure.;
UNII : INU8H2KAWG;
InChIKey : TVURRHSHRRELCG-UHFFFAOYSA-N;
CAS number : 67227-56-9;
Chemical formula : C16H16ClNO3;
ChEBI ID : CHEBI:5002;
Origin ID : C61759;
UMLS CUI : C0060180;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
