" /> Epiandrosterone - CISMeF





Preferred Label : Epiandrosterone;

NCIt definition : A dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property. Epiandrosterone, a potential neurosteroid, appears to bind to the gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator of GABA-RC as well as signal through the N-methyl-D-aspartate receptor. In addition this agent inhibits the pentose phosphate pathway (PPP) thereby dilating blood vessels pre-contracted by partial depolarization. Also, epiandrosterone inhibits the synthesis of thromboxane A2 in activated platelets, reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen, increases serum levels of insulin-like growth factor 1 and increases cyclic guanosine monophosphate and nitric oxide synthesis. These effects may improve circulation in the microvasculature.;

UNII : 8TR252Z538;

InChIKey : QGXBDMJGAMFCBF-LUJOEAJASA-N;

CAS number : 481-29-8;

Chemical formula : C19H30O2;

ChEBI ID : CHEBI:541975;

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30/05/2025


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