" /> Emedastine - CISMeF





Preferred Label : Emedastine;

NCIt definition : A second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.;

UNII : 9J1H7Y9OJV;

InChIKey : KBUZBQVCBVDWKX-UHFFFAOYSA-N;

CAS number : 87233-61-2;

Chemical formula : C17H26N4O;

ChEBI ID : CHEBI:4779;

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28/05/2025


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