Edetate Disodium

Preferred Label : Edetate Disodium;

NCIt definition : The disodium salt form of edetate, a heavy metal chelating agent with anti-hypercalcemic and anti-arrhythmic properties. Edetate, a heavy metal antagonist, chelates divalent and trivalent metals, forming soluble stable complexes which are readily excreted by the kidneys, thereby can be used to lower serum calcium concentrations. In addition, this agent exerts a negative inotropic effect on the heart through a transiently induced hypocalcemic state, thereby antagonizing the inotropic and chronotropic effects of digitalis glycosides on the ventricles of the heart. Upon ocular administration, edetate exerts its ophthalmic effect by chelating calcium to form soluble complexes, thereby removing corneal calcium deposits.;

UNII : 7FLD91C86K;

InChIKey : OVBJJZOQPCKUOR-UHFFFAOYSA-L;

CAS number : 6381-92-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 6381-92-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C10H12N2O8.2H.2Na.2H2O;

ChEBI ID : CHEBI:64758;

Details

Origin ID

C61741;

UMLS CUI

C0012695;

Automatic exact mappings (from CISMeF team)
- Disodium edetate [ICHI extension code]
- edetic acid [MeSH Descriptor]
Currated CISMeF NLP mapping
- Edetate disodium (product) [Inactive SNOMED CT concept]
- Edetate disodium (substance) [SNOMED CT concept]
- edetate disodium [SNOMED Notion]
- edetic acid, disodium salt [MeSH concept]
- edetic acid, sodium salt [Substance BNPC]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Edetate disodium (product) [Inactive SNOMED CT concept]
- Edetate disodium (substance) [SNOMED CT concept]
- Sodium edetate [ICD-11 Extension code]
- edetate disodium [SNOMED Notion]
- edetic acid, disodium salt [MeSH concept]
- edetic acid, sodium salt [Substance BNPC]
- sodium edetate [ATC Code]
Validated automatic mappings to NTBT
- Disodium edetate [ICD-11 Extension code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Edetic Acid [NCIt concept]
is_salt_form_of
- Edetic Acid [NCIt concept]

Keyword's position in hierarchy(ies) :

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