" /> Dobutamine - CISMeF





Preferred Label : Dobutamine;

NCIt definition : A synthetic catecholamine with sympathomimetic activity. Dobutamine is a direct-acting inotropic agent and an adrenergic agonist that stimulates primarily the beta-1 adrenoceptor, with lesser effect on beta-2 or alpha receptors. Via beta-1 adrenoceptor of the heart, this agent induces positive inotropic effect with minimal changes in chronotropic activities or systemic vascular resistance. Dobutamine also causes vasodilation by stimulating beta-2 adrenergic receptors in blood vessels, augmented by reflex vasoconstriction resulting in increased cardiac output.;

Alternative definition : ACC/AHA: Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the β receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects.;

UNII : 3S12J47372;

InChIKey : JRWZLRBJNMZMFE-UHFFFAOYSA-N;

CAS number : 34368-04-2;

Chemical formula : C18H23NO3;

ChEBI ID : CHEBI:4670;

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10/05/2025


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