NCIt definition : A derivative of streptomycin, aminoglycoside antibiotic, with bactericidal property.
Dihydrostreptomycin depends on active transport across the bacterial cell membrane
before irreversibly binding S12 protein of the bacterial 30S ribosomal subunit. As
a result, this agent interferes with the initiation complex between messenger RNA
and the bacterial ribosome thereby causing the misreading of the genetic code resulting
in the production of non-functional proteins, consequently leading to bacterial cell
death.;