Propoxyphene, ( /-)-

Preferred Label : Propoxyphene, ( /-)-;

NCIt synonyms : DL-Propoxyphene;

NCIt definition : A racemic mixture of propoxyphene, a synthetic opiate agonist with narcotic analgesic activity. The analgesic effect of propoxyphene is due to its d-isomer, dextropropoxyphene, which bind to opiate receptors, primarily the OP3 receptor located within the central nervous system (CNS). Mediated through G-protein coupled OP3 receptors and cAMP signaling, the release of nociceptive neurotransmitters such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline is inhibited. Propoxyphene also inhibits the release of vasopressin, somatostatin, insulin and glucagon and close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability.;

UNII : II2G62OV6F;

CAS number : 2621-61-6;

Chemical formula : C22H29NO2;

Details

Origin ID

C61711;

UMLS CUI

C1880235;

Automatic exact mappings (from CISMeF team)
- Product containing dextropropoxyphene (medicinal product) [SNOMED CT concept]
- Propoxyphene [LOINC component]
- Propoxyphene [ICD-11 Extension code]
- Propoxyphene [ICHI extension code]
- dextropropoxyphene [MeSH Descriptor]
- propoxyphene [SNOMED Notion]
- propoxyphene [EMDN type]
- propoxyphene [medical devices type]
See also inter- (CISMeF)
- Dextropropoxyphene (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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