NCIt definition : The maleate salt form of dexbrompheniramine, an alkylamine derivative with anticholinergic
and sedative properties. Dexbrompheniramine is a histamine H1-receptor antagonist
that competes with histamine for the H1-receptor sites on effector cells in the gastrointestinal
tract, blood vessels and respiratory tract. The antagonistic action of this agent
blocks the activities of endogenous histamine, which subsequently leads to temporary
relief from the negative histamine-mediated symptoms of allergic reaction such as
bronchoconstriction, vasodilation, increased capillary permeability and spasmodic
contractions of gastrointestinal smooth muscle.;