NCIt definition : A synthetic phenethylamine bicyclic derivative with antidepressant activity. Desvenlafaxine
is a selective reuptake inhibitor of serotonin and norepinephrine due to its high
binding affinities to the pre-synaptic serotonin and norepinephrine transporters.
By blocking both transporters, this agent prolongs neurotransmitter activities of
both serotonin and norepinephrine, thereby alleviating depressive state.;