NCIt definition : An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative
of the antidepressant. Desipramine enhances monoamine neurotransmission in certain
areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the
noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation
through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage.;