NCIt definition : A bicyclic phthalene derivative and selective serotonin reuptake inhibitor (SSRI),
with antidepressant and anxiolytic activities. Citalopram selectively inhibits the
neuronal reuptake of the neurotransmitter serotonin (5-HT) in presynaptic cells in
the central nervous system, thereby increasing levels of 5-HT within the synaptic
cleft and enhancing the actions of serotonin on its receptors. Increased serotonergic
neurotransmission results in antidepressive and anxiolytic effects.;