NCIt definition : A semi-synthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin
antibiotic derived from cephalosporium. The bactericidal activity of cefotetan disodium
is caused by an inhibition of bacterial cell wall synthesis via inhibition of cross-linking
of peptidoglycans. This results in a reduction of cell wall stability and causes cell
lysis. Cefotetan disodium is more active against gram-negative organisms and less
active against gram-positive organisms compared to first-generation cephalosporins.;