Preferred Label : Andrographolide;
NCIt synonyms : 2(3H)-Furanone, 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-,
(1R-(1-alpha(E(S*)),4a-beta,5-alpha,6-alpha,8a-alpha))-; (1R-(1-alpha(E(S)),4a-beta,5alpha,6alpha,8a-alpha))-3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-2(3H)-furanone; 3alpha,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid gamma-Lactone; 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one; Andrographis; (3E,4S)-4-hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one; (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one;
NCIt definition : A labdane diterpenoid that is produced by the Andrographis paniculata plant, which
has a broad range of therapeutic applications including anti-inflammatory and anti-platelet
aggregation activities and potential antineoplastic properties. Since andrographolide
has multiple therapeutic activities there are several proposed mechanisms of action
for this agent. The anti-inflammatory effects of this agent appear to be related to
the inhibition of nitric oxide (NO) production by macrophages. This agent may activate
the NO/cyclic GMP pathway and inhibit both the phospholipase C gamma 2 (PLC gamma2)/protein
kinase C (PKC) and PI3K/AKT-MAPK signaling pathways in activated platelets to inhibit
platelet aggregation. In activated platelets, these three signaling pathways are downstream
of integrin activation mediated by collagen binding and influence the association
of fibrinogen with its receptors. Additionally, andrographolide may exert its anti-cancer
activity through the induction of cell cycle arrest at G0/G1 phase and the stimulation
of lymphocyte proliferation and activation. These processes could result in decreased
proliferation of and increased immunocytotoxicity against tumor cells.;
UNII : 410105JHGR;
InChIKey : BOJKULTULYSRAS-OTESTREVSA-N;
CAS number : 5508-58-7;
Chemical formula : C20H30O5;
ChEBI ID : CHEBI:65408;
Origin ID : C61637;
UMLS CUI : C0051821;
Currated CISMeF NLP mapping
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
