Preferred Label : Acetyl-L-Carnitine Hydrochloride;
NCIt synonyms : Acetylcarnitine L-form HCl; Acetylcarnitine Hydrochloride, L-; o-Acetyl-L-carnitine hydrochloride; 1-Propanaminium, 2-(acetyloxy)-3-carboxy-N,N,N-trimethyl-, chloride, (R)-;
NCIt related terms : LEVACECARNINE HYDROCHLORIDE;
NCIt definition : A nutritional supplement composed of the hydrochloride salt form of the acetylated
form of the endogenously produced L-carnitine, with potential neuroprotective, cognitive-enhancing,
anti-depressive and immunomodulating activities. L-carnitine is responsible for the
transport of fatty acids into the mitochondria for breakdown. It may also relieve
peripheral neuropathy induced by chemotherapy, diabetes or other diseases. In addition,
acetyl-L-carnitine may modulate the immune response by increasing T-lymphocytes maturation
and may downregulate pro-inflammatory cytokines in response to viruses, such as SARS-CoV-2.
It may also disrupt the ACE2 signaling pathway and inhibit the production of reactive
oxygen species (ROS).;
Alternative definition : NCI-GLOSS: A form of the natural substance carnitine that is being studied as a way
to prevent tissue damage caused by chemotherapy. Carnitine is made in muscle and liver
tissue and is found in certain foods, such as meat, poultry, fish, and some dairy
products. It is used by many cells in the body to make energy from fat.;
UNII : NDW10MX58T;
InChIKey : JATPLOXBFFRHDN-DDWIOCJRSA-N;
CAS number : 5080-50-2;
Chemical formula : C9H18NO4.Cl;
Codes from synonyms : CDR0000641987;
Origin ID : C61624;
UMLS CUI : C1879535;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
