NCIt definition : A triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic
activity against breast cancer. Clomiphene has both estrogenic and anti-estrogenic
activities that compete with estrogen for binding at estrogen receptor sites in target
tissues. This agent causes the release of the pituitary gonadotropins follicle stimulating
hormone (FSH) and luteinizing hormone (LH), leading to ovulation. (NCI04);