Preferred Label : Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine;
NCIt synonyms : KGEL Vaccine; Hodgkin s Antigens-GM-CSF-Expressing Cell Vaccine;
NCIt definition : An allogeneic vaccine consisting of Hodgkin lymphoma cells transfected with the granulocyte
macrophage-colony-stimulating factor (GM-CSF) gene with potential antineoplastic activity.
Upon vaccination, Hodgkin antigens-GM-CSF-expressing cell vaccine may stimulate a
cytotoxic T-lymphocyte (CTL) immune response against Hodgkin lymphoma-associated antigens,
which may result in the lysis of tumor cells expressing these antigens. In addition,
transfected Hodgkin lymphoma cells secrete GM-CSF, which may potentiate the CTL response
against Hodgkin lymphoma-associated antigens.;
Origin ID : C61592;
UMLS CUI : C1831712;
Semantic type(s)
- concept_is_in_subset
