Preferred Label : Nitrogen Mustard Prodrug PR-104;
NCIt synonyms : PR104; ((2-Bromoethyl)-2,4-dinitro-6-(((2-(phosphonooxy)ethyl)amino)-carbonyl)anilino)ethyl
Methanesulphonate;
NCIt related terms : PR-104;
NCIt definition : A non-toxic, small-molecule, hypoxia-activated, 3,5-dinitrobenzamide nitrogen mustard
pre-prodrug with potential antitumor activity. Upon intravenous administration, PR-104
is converted by systemic phosphatases to the alcohol intermediate PR-104A, which is
reduced to form the active DNA-crosslinking mustard species hydroxylamine PR-104H
intracellularly under hypoxic conditions. PR-104H specifically crosslinks hypoxic
tumor cell DNA, resulting in the inhibition of DNA repair and synthesis, cell-cycle
arrest, and apoptosis in susceptible hypoxic tumor cell populations while sparing
normoxic tissues.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. PR-104 becomes active
when cancer cells don't receive enough oxygen. It may kill cancer cells by damaging
their DNA.;
UNII : V16D2ZT7DT;
InChIKey : GZSOKPMDWVRVMG-UHFFFAOYSA-N;
CAS number : 851627-62-8;
Molecule name : PR-104;
Codes from synonyms : CDR0000514449;
Origin ID : C61590;
UMLS CUI : C1831907;
Automatic exact mappings (from CISMeF team)
- PR-104 [MeSH Supplementary Concept]
Semantic type(s)
UMLS correspondences (same concept)
- PR-104 [MeSH Supplementary Concept]
concept_is_in_subset
has_target