Preferred Label : Cantuzumab Ravtansine;
NCIt related terms : huC242-DM4; maytansinoid DM4-conjugated humanized monoclonal antibody huC242;
NCIt definition : An immunotoxin of a humanized monoclonal antibody C242 (MoAb HuC242) conjugated to
a derivative of the cytotoxic agent maytansine, DM4, with potential antitumor activity.
Cantuzumab ravtansine is generated from MoAb C242, which is raised against a cell
surface superantigen, CA242, found in a variety of human tumor cells. Upon binding
and entry, the immunoconjugate releases the maytansinoid agent DM4, which binds to
tubulin, thereby affecting microtubule assembly/disassembly dynamics. As a result,
this agent prevents cell division and reduces cell growth of cancer cells that express
CA242.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. It
is made by linking the monoclonal antibody huC242 to a toxic substance called maytansinoid
DM4. The monoclonal antibody binds to the surfaces of cancer cells and the maytansinoid
DM4 enters the cells and blocks their growth. It is a type of immunotoxin.;
UNII : RNQ8JQ4R9P;
CAS number : 868747-45-9;
Molecule name : IMGN242;
Codes from synonyms : CDR0000518303; CDR0000539484;
Origin ID : C61576;
UMLS CUI : C1831909;
Semantic type(s)
- concept_is_in_subset
- has_target
