Preferred Label : APF530;
NCIt synonyms : APF-530;
NCIt definition : A controlled-release formulation of a biodegradable poly(ortho ester) polymer, encapsulating
the indazole derivative granisetron, with antiemetic activity. Upon administration
of APF530, the polymer slowly erodes and releases the active ingredient granisetron.
As a selective serotonin receptor antagonist, granisetron competitively blocks the
action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression
of nausea and vomiting over a sustained period of time.;
Origin ID : C61567;
UMLS CUI : C1831918;
Semantic type(s)
- concept_is_in_subset
