" /> Tubulin Binding Agent TTI-237 - CISMeF





Preferred Label : Tubulin Binding Agent TTI-237;

Obsolete resource : true;

NCIt synonyms : TTI-237;

NCIt related terms : TTI-237;

NCIt definition : A small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. TTI-237 stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called mitotic inhibitors.;

NCIt note : See 'Cevipabulin(C77064)';

Concept status : Retired_Concept;

Codes from synonyms : CDR0000438726;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
08/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.