Recombinant Human Hyaluronidase

Preferred Label : Recombinant Human Hyaluronidase;

NCIt synonyms : Hyaluronidase Recombinant Human; rHuPH20; Hyaluronidase-oysk;

NCIt related terms : HYALURONIDASE (HUMAN RECOMBINANT);

NCIt definition : A human recombinant form of the naturally occurring human enzyme hyaluronidase with potential chemoadjuvant activity. Upon local administration, recombinant human hyaluronidase hydrolyzes hyaluronic acid, a glucosaminoglycan responsible for the viscosity of the interstitial barrier. The digestion of hyaluronic acid lowers the viscosity in the interstitial space, thereby increasing permeability and facilitating local penetration of chemotherapeutic agents into cancer cells.;

UNII : 743QUY4VD8;

CAS number : 757971-58-7;

Drug name : Hylenex; Chemophase;

Details

Origin ID

C61504;

UMLS CUI

C1720035;

Currated CISMeF NLP mapping
- Recombinant human hyaluronidase (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing recombinant human hyaluronidase (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing recombinant human hyaluronidase (medicinal product) [SNOMED CT concept]
- Recombinant human hyaluronidase (substance) [SNOMED CT concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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