NCIt definition : A broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole
strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition
of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important
component of the fungal cell wall. Inhibition of ergosterol synthesis changes the
fungal cell membrane composition and integrity, alters membrane permeability and eventually
leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a
significantly more potent inhibitor of sterol 14-alpha demethylase.;
Semantic type(s)